Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection.
Identifieur interne : 00AA02 ( Main/Exploration ); précédent : 00AA01; suivant : 00AA03Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection.
Auteurs : P K Murthy [Inde] ; K. Tyagi ; R P Ghosh ; P S Murthy ; R K ChatterjeeSource :
- Parasitology [ 0031-1820 ] ; 1999.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Cercopithecidae (parasitologie), Complexe antigène-anticorps (sang), Filariose lymphatique (immunologie), Filariose lymphatique (médecine vétérinaire), Filarioses (immunologie), Filarioses (médecine vétérinaire), Hydrocèle, Maladies des singes (immunologie), Mâle, Oedème, Porteur sain, Spécificité des anticorps, Test ELISA.
- MESH :
- immunologie : Antigènes d'helminthe, Brugia malayi, Filariose lymphatique, Filarioses, Maladies des singes.
- médecine vétérinaire : Filariose lymphatique, Filarioses.
- parasitologie : Cercopithecidae.
- sang : Anticorps antihelminthe, Complexe antigène-anticorps.
- Animaux, Hydrocèle, Mâle, Oedème, Porteur sain, Spécificité des anticorps, Test ELISA.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Antibody Specificity, Antigen-Antibody Complex (blood), Antigens, Helminth (immunology), Brugia malayi (immunology), Carrier State, Cercopithecidae (parasitology), Edema, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (veterinary), Enzyme-Linked Immunosorbent Assay, Filariasis (immunology), Filariasis (veterinary), Male, Monkey Diseases (immunology), Testicular Hydrocele.
- MESH :
- chemical , blood : Antibodies, Helminth, Antigen-Antibody Complex.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia malayi, Elephantiasis, Filarial, Filariasis, Monkey Diseases.
- parasitology : Cercopithecidae.
- veterinary : Elephantiasis, Filarial, Filariasis.
- Animals, Antibody Specificity, Carrier State, Edema, Enzyme-Linked Immunosorbent Assay, Male, Testicular Hydrocele.
Abstract
Humoral immune responses of the Indian leaf monkey (Presbytis entellus) experimentally infected with Brugia malayi and exhibiting disease manifestations were studied. Microfilaraemia, filaria-specific IgG and circulating immune complexes (CICs) were determined in the monkeys at different time-points after inoculation of B. malayi 3rd-stage larvae. Sera were analysed for recognition pattern of adult parasite antigen molecules by immunoblotting. More than 60% of the infected monkeys developed episodic or persistent limb oedema with or without fever and with low or no microfilaraemia. While both CIC and filaria specific IgG levels were comparable in animals showing no disease symptoms (asymptomatics) and some animals showing symptoms (symptomatics), IgG levels peaked during pre-patent stage in symptomatics and during latent stage in asymptomatic animals. However, some of the symptomatic animals showed a low level of filaria-specific IgG as compared to asymptomatic and other symptomatic animals. The immunoblot analysis showed non-reactivity of 17 and 55 kDa antigens with sera of symptomatic animals. The results thus suggest that humoral immune responses as measured in the present study do not precede the development of the manifestations. However, 2 non-reactive antigen molecules identified by symptomatic sera need further study to establish their possible involvement, if any, in the development of acute disease manifestations in this model.
PubMed: 10446704
Affiliations:
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Tyagi</name></author><author><name sortKey="Ghosh, R P" sort="Ghosh, R P" uniqKey="Ghosh R" first="R P" last="Ghosh">R P Ghosh</name></author><author><name sortKey="Murthy, P S" sort="Murthy, P S" uniqKey="Murthy P" first="P S" last="Murthy">P S Murthy</name></author><author><name sortKey="Chatterjee, R K" sort="Chatterjee, R K" uniqKey="Chatterjee R" first="R K" last="Chatterjee">R K Chatterjee</name></author></analytic><series><title level="j">Parasitology</title><idno type="ISSN">0031-1820</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Antibody Specificity</term><term>Antigen-Antibody Complex (blood)</term><term>Antigens, Helminth (immunology)</term><term>Brugia malayi (immunology)</term><term>Carrier State</term><term>Cercopithecidae (parasitology)</term><term>Edema</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (veterinary)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Filariasis (immunology)</term><term>Filariasis (veterinary)</term><term>Male</term><term>Monkey Diseases (immunology)</term><term>Testicular Hydrocele</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia malayi (immunologie)</term><term>Cercopithecidae (parasitologie)</term><term>Complexe antigène-anticorps (sang)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (médecine vétérinaire)</term><term>Filarioses (immunologie)</term><term>Filarioses (médecine vétérinaire)</term><term>Hydrocèle</term><term>Maladies des singes (immunologie)</term><term>Mâle</term><term>Oedème</term><term>Porteur sain</term><term>Spécificité des anticorps</term><term>Test ELISA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigen-Antibody Complex</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia malayi</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Maladies des singes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Monkey Diseases</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Cercopithecidae</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Cercopithecidae</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Complexe antigène-anticorps</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Specificity</term><term>Carrier State</term><term>Edema</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Male</term><term>Testicular Hydrocele</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Hydrocèle</term><term>Mâle</term><term>Oedème</term><term>Porteur sain</term><term>Spécificité des anticorps</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Humoral immune responses of the Indian leaf monkey (Presbytis entellus) experimentally infected with Brugia malayi and exhibiting disease manifestations were studied. Microfilaraemia, filaria-specific IgG and circulating immune complexes (CICs) were determined in the monkeys at different time-points after inoculation of B. malayi 3rd-stage larvae. Sera were analysed for recognition pattern of adult parasite antigen molecules by immunoblotting. More than 60% of the infected monkeys developed episodic or persistent limb oedema with or without fever and with low or no microfilaraemia. While both CIC and filaria specific IgG levels were comparable in animals showing no disease symptoms (asymptomatics) and some animals showing symptoms (symptomatics), IgG levels peaked during pre-patent stage in symptomatics and during latent stage in asymptomatic animals. However, some of the symptomatic animals showed a low level of filaria-specific IgG as compared to asymptomatic and other symptomatic animals. The immunoblot analysis showed non-reactivity of 17 and 55 kDa antigens with sera of symptomatic animals. The results thus suggest that humoral immune responses as measured in the present study do not precede the development of the manifestations. However, 2 non-reactive antigen molecules identified by symptomatic sera need further study to establish their possible involvement, if any, in the development of acute disease manifestations in this model.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Chatterjee, R K" sort="Chatterjee, R K" uniqKey="Chatterjee R" first="R K" last="Chatterjee">R K Chatterjee</name><name sortKey="Ghosh, R P" sort="Ghosh, R P" uniqKey="Ghosh R" first="R P" last="Ghosh">R P Ghosh</name><name sortKey="Murthy, P S" sort="Murthy, P S" uniqKey="Murthy P" first="P S" last="Murthy">P S Murthy</name><name sortKey="Tyagi, K" sort="Tyagi, K" uniqKey="Tyagi K" first="K" last="Tyagi">K. Tyagi</name></noCountry><country name="Inde"><noRegion><name sortKey="Murthy, P K" sort="Murthy, P K" uniqKey="Murthy P" first="P K" last="Murthy">P K Murthy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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